Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.

PloS one - 1 Jan 2014

Cook Mandy, Bolkan Bonnie J, Kretzschmar Doris

Abstract excerpt

loechrig (loe) mutant flies are characterized by progressive neuronal degeneration, behavioral deficits, and early death. The mutation is due to a P-element insertion in the gene for the γ-subunit of the trimeric AMP-activated protein kinase (AMPK) complex, whereby the insertion affects only one of several alternative transcripts encoding a unique neuronal isoform. AMPK is a cellular energy sensor that regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to AMP-Activated Protein Kinases
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoprotein Phosphatases

Share to Polymerization

Share to Protein Prenylation

Share to Protein Stability

Share to rho GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24587072
DOI: 10.1371/journal.pone.0089847
PMCID: PMC3934941

Genes

SSH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased actin polymerization and stabilization interferes with neuronal function and survival in the AMPKγ mutant Loechrig.PMID 24587072Read ↗

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration.Semantic proximity Read ↗

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing.Semantic proximity Read ↗

The AMPK-related kinase SNARK regulates muscle mass and myocyte survivalSemantic proximity Read ↗

SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy.Semantic proximity Read ↗

Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.Semantic proximity Read ↗

Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.Semantic proximity Read ↗

Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L.Semantic proximity Read ↗

Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.Semantic proximity Read ↗

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases.Semantic proximity Read ↗

Drosophila alicorn is a neuronal maintenance factor protecting against activity-induced retinal degeneration.Semantic proximity Read ↗

Nuclear localization of SNARK; its impact on gene expression.Semantic proximity Read ↗

The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.