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Article

Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.

The Journal of biological chemistry - 13 Oct 2017

Dong Shengli, Baranwal Somesh, Garcia Anapatricia, Serrano-Gomez Silvia J, Eastlack Steven, Iwakuma Tomoo, Mercante Donald, Mauvais-Jarvis Franck, Alahari Suresh K

Abstract excerpt

Nischarin (Nisch) is a key protein functioning as a molecular scaffold and thereby hosting interactions with several protein partners. To explore the physiological importance of Nisch, here we generated Nisch loss-of-function mutant mice and analyzed their metabolic phenotype. Nisch-mutant embryos exhibited delayed development, characterized by small size and attenuated weight gain. We uncovered the reason for...

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Identifiers

PMID: 28842496
DOI: 10.1074/jbc.M117.784256
PMCID: PMC5641867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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