Article
Nuclear localization of SNARK; its impact on gene expression.
Biochemical and biophysical research communications - 26 Dec 2008
Kuga Wataru, Tsuchihara Katsuya, Ogura Tsutomu, Kanehara Sakyo, Saito Marie, Suzuki Atsushi, Esumi Hiroyasu
Abstract excerpt
SNARK, a member of the AMPK-related kinases, has been involved in the cellular stress responses but its precise mechanisms remain unclear. Subcellular localization of SNARK protein was identified. Unlike cytoplasmic localizing AMPKalpha, SNARK was predominantly localized in the nucleus. SNARK was constitutively distributed in the nucleus even when SNARK was activated by metabolic stimuli such as AICAR and...
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