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Article

The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing.

The EMBO journal - 2 Dec 2002

Tschäpe Jakob-Andreas, Hammerschmied Christine, Mühlig-Versen Max, Athenstaedt Karin, Daum Günther, Kretzschmar Doris

Abstract excerpt

The novel Drosophila mutant löchrig (loe) shows progressive neurodegeneration and neuronal cell death, in addition to a low level of cholesterol ester. loe affects a specific isoform of the gamma-subunit of AMP-activated protein kinase (AMPK), a negative regulator of hydroxymethylglutaryl (HMG)-CoA reductase and cholesterol synthesis in vertebrates. Although Drosophila cannot synthesize cholesterol de novo, the...

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Identifiers

PMID: 12456644
DOI: 10.1093/emboj/cdf636
PMCID: PMC136940

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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