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Article

The Saccharomyces cerevisiae AMPK, Snf1, Negatively Regulates the Hog1 MAPK Pathway in ER Stress Response.

PLoS genetics - 1 Jan 2015

Mizuno Tomoaki, Masuda Yuto, Irie Kenji

Abstract excerpt

Accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) causes ER stress. Snf1, the Saccharomyces cerevisiae ortholog of AMP-activated protein kinase (AMPK), plays a crucial role in the response to various environmental stresses. However, the role of Snf1 in ER stress response remains poorly understood. In this study, we characterize Snf1 as a negative regulator of Hog1 MAPK in ER stress...

Topics

Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Gene Expression Regulation, Fungal
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases
Mutation
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Unfolded Protein Response

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26394309
DOI: 10.1371/journal.pgen.1005491
PMCID: PMC4578879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26394309-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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