Article
Homo-oligomerization and activation of AMP-activated protein kinase are mediated by the kinase domain alphaG-helix.
The Journal of biological chemistry - 2 Oct 2009
Scholz Roland, Suter Marianne, Weimann Théodore, Polge Cécile, Konarev Petr V, Thali Ramon F, Tuerk Roland D, Viollet Benoit, Wallimann Theo, Schlattner Uwe, Neumann Dietbert
Abstract excerpt
AMP-activated protein kinase (AMPK) is a heterotrimeric complex playing a crucial role in maintaining cellular energy homeostasis. Recently, homodimerization of mammalian AMPK and yeast ortholog SNF1 was shown by us and others. In SNF1, it involved specific hydrophobic residues in the kinase domain alphaG-helix. Mutation of the corresponding AMPK alpha-subunit residues (Val-219 and Phe-223) to glutamate reduced...
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