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Article

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration.

PloS one - 1 Jan 2012

Cook Mandy, Mani Priya, Wentzell Jill S, Kretzschmar Doris

Abstract excerpt

The Drosophila mutant loechrig (loe) shows age-dependent degeneration of the nervous system and is caused by the loss of a neuronal isoform of the AMP-activated protein kinase (AMPK) γ-subunit (also known as SNF4Aγ). The trimeric AMPK complex is activated by low energy levels and metabolic insults and regulates multiple important signal pathways that control cell metabolism. A well-known downstream target of AMPK...

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Identifiers

PMID: 22970217
DOI: 10.1371/journal.pone.0044440
PMCID: PMC3435293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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