Article
Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers.
PloS one - 1 Jan 2014
Kittel Anja, Müller Fabian, König Jörg, Mieth Maren, Sticht Heinrich, Zolk Oliver, Kralj Ana, Heinrich Markus R, Fromm Martin F, Maas Renke
Abstract excerpt
Elevated plasma concentrations of asymmetric (ADMA) and symmetric (SDMA) dimethylarginine have repeatedly been linked to adverse clinical outcomes. Both methylarginines are substrates of alanine-glyoxylate aminotransferase 2 (AGXT2). It was the aim of the present study to simultaneously investigate the functional relevance and relative contributions of common AGXT2 single nucleotide polymorphisms (SNPs) to plasma...
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