Article
The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans.
European journal of applied physiology - 1 Dec 2020
Stautemas Jan, Jarzebska Natalia, Shan Zhou Xiang, Blancquaert Laura, Everaert Inge, de Jager Sarah, De Baere Siegrid, Hautekiet Arne, Volkaert Anneke, Lefevere Filip B D, Martens-Lobenhoffer Jens, Bode-Böger Stefanie M, Kim Chang Keun, Leiper James, Weiss Norbert, Croubels Siska, Rodionov Roman N, Derave Wim
Abstract excerpt
PURPOSE: Chronic β-alanine supplementation leads to increased levels of muscle histidine-containing dipeptides. However, the majority of ingested β-alanine is, most likely, degraded by two transaminases: GABA-T and AGXT2. In contrast to GABA-T, the in vivo role of AGXT2 with respect to β-alanine metabolism is unknown. The purpose of the present work is to investigate if AGXT2 is functionally involved in β-alanine...
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