Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.

doi:10.1038/srep35503

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Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2.

Scientific reports - 18 Oct 2016

Burdin Dmitry V, Kolobov Alexey A, Brocker Chad, Soshnev Alexey A, Samusik Nikolay, Demyanov Anton V, Brilloff Silke, Jarzebska Natalia, Martens-Lobenhoffer Jens, Mieth Maren, Maas Renke, Bornstein Stefan R, Bode-Böger Stefanie M, Gonzalez Frank, Weiss Norbert, Rodionov Roman N

Abstract excerpt

Elevated levels of circulating asymmetric and symmetric dimethylarginines (ADMA and SDMA) predict and potentially contribute to end organ damage in cardiovascular diseases. Alanine-glyoxylate aminotransferase 2 (AGXT2) regulates systemic levels of ADMA and SDMA, and also of beta-aminoisobutyric acid (BAIB)-a modulator of lipid metabolism. We identified a putative binding site for hepatic nuclear factor 4 α...

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PMID: 27752141
DOI: 10.1038/srep35503
PMCID: PMC5067591

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AGXT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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