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Article

Effects of AGXT2 variants on blood pressure and blood sugar among 750 older Japanese subjects recruited by the complete enumeration survey method.

BMC genomics - 20 Apr 2021

Yoshino Yuta, Kumon Hiroshi, Mori Takaaki, Yoshida Taku, Tachibana Ayumi, Shimizu Hideaki, Iga Jun-Ichi, Ueno Shu-Ichi

Abstract excerpt

BACKGROUND: Alanine:glyoxylate aminotransferase 2 (AGXT2; EC 2.6.1.44) is the only enzyme that degrades the R-form of 3-aminoisobutyrate, an intermediate metabolite of thymine. AGXT2, as well as diaminoarginine dimethylaminohydrolase 1 (DDAH1; EC 3.5.3.18), works as an enzyme that degrades asymmetric dimethylarginine (ADMA), which competitively inhibits the nitric oxide synthase family. Thus, these two enzyme...

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Identifiers

PMID: 33879046
DOI: 10.1186/s12864-021-07612-3
PMCID: PMC8059213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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