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Article

Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population.

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Yoshino Y, Kohara K, Abe M, Ochi S, Mori Y, Yamashita K, Igase M, Tabara Y, Mori T, Miki T, Ueno S

Abstract excerpt

Alanine:glyoxylate aminotransferase 2 (AGXT2; EC 2.6.1.44) degrades asymmetric dimethylarginine (ADMA), a competitive inhibitor of nitric oxide (NO) synthase. Increased ADMA, reduced NO, and hypertension are shown in Agxt2 knockout mice. There are four single nucleotide polymorphisms (rs37370, rs37369, rs180749, and rs16899974) with which AGXT2 activity changes in humans and may be related to vulnerability of...

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Identifiers

PMID: 25620171

Genes

AGXT2

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Related research

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Missense variants of the alanine: glyoxylate aminotransferase 2 gene correlated with carotid atherosclerosis in the Japanese population.PMID 25620171Read ↗

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Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke.Semantic proximity Read ↗

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Considerable impacts of AGXT2 V140I polymorphism on chronic heart failure in the Chinese population.Semantic proximity Read ↗

Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients.Semantic proximity Read ↗

Overexpression of Alanine-glyoxylate aminotransferase 2 Protects from Asymmetric Dimethylarginine-induced Endothelial Dysfunction and Aortic RemodelingSemantic proximity Read ↗

Genetic variations in the alanine-glyoxylate aminotransferase 2 (AGXT2) gene and dimethylarginines levels in rheumatoid arthritis.Semantic proximity Read ↗

Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers.Semantic proximity Read ↗

TaqI polymorphism at the alanine:glyoxylate aminotransferase (AGXT) gene locus.Semantic proximity Read ↗

Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals.Semantic proximity Read ↗

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