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Article

Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients.

Progress in neuro-psychopharmacology & biological psychiatry - 4 Aug 2014

Yoshino Yuta, Abe Masao, Numata Shusuke, Ochi Shinichiro, Mori Yoko, Ishimaru Takashi, Kinoshita Makoto, Umehara Hidehiro, Yamazaki Kiyohiro, Mori Takaaki, Ohmori Tetsuro, Ueno Shu-ichi

Abstract excerpt

Alanine:glyoxylate aminotransferase 2 (AGXT2) is the only enzyme that degrades D-3-aminoisobutyrate (D-AIB), which is an intermediate product of thymine, and 30-40% of Japanese lack AGXT2 activity genetically and excrete high amounts of D-AIB in their urine. Recently, AGXT2 is reported to metabolize asymmetric dimethyl arginine (ADMA), a competitive inhibitor of nitric oxide (NO) synthase. Since AGXT2 is...

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Source

Identifiers

PMID: 24727203
DOI: 10.1016/j.pnpbp.2014.04.002

Genes

AGXT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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