Article
Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation.
Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2012
Ji Yuan, Nordgren Kendra K S, Chai Yubo, Hebbring Scott J, Jenkins Gregory D, Abo Ryan P, Peng Yi, Pelleymounter Linda L, Moon Irene, Eckloff Bruce W, Chai Xiaoshan, Zhang Jianping, Fridley Brooke L, Yee Vivien C, Wieben Eric D, Weinshilboum Richard M
Abstract excerpt
The "methionine cycle" plays a critical role in the regulation of concentrations of (S)-adenosylmethionine (AdoMet), the major biological methyl donor. We set out to study sequence variation in genes encoding the enzyme that synthesizes AdoMet in liver, methionine adenosyltransferase 1A (MAT1A) and the major hepatic AdoMet using enzyme, glycine N-methyltransferase (GNMT), as well as functional implications of...
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