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Article

Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation.

Expert opinion on drug metabolism & toxicology - 1 Sept 2013

Badenhorst Christoffel Petrus Stephanus, van der Sluis Rencia, Erasmus Elardus, van Dijk Alberdina Aike

Abstract excerpt

INTRODUCTION: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A (CoASH). However, because of the small number of pharmaceutical drugs that are conjugated to glycine, the pathway has not yet been characterized in detail. Here, we review the causes and...

Topics

Acyltransferases
Coenzyme A
Glycine
Hepatitis
Humans
Hydroxybenzoates
Inactivation, Metabolic
Kidney
Liver
Liver Neoplasms
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Musculoskeletal Development

Polymorphism, Single Nucleotide

Xenobiotics

Source

Identifiers

PMID: 23650932
DOI: 10.1517/17425255.2013.796929

Genes

GLYAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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