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Article

The impact of message mutation on the fitness of a genetic code.

Journal of molecular evolution - 1 May 2002

Sella Guy, Ardell David H

Abstract excerpt

The Standard Genetic Code is organized such that similar codons encode similar amino acids. One explanation suggested that the Standard Code is the result of natural selection to reduce the fitness "load" that derives from the mutation and mistranslation of protein-coding genes. We review the arguments against the mutational load-minimizing hypothesis and argue that they need to be reassessed. We review recent...

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PMID: 11965436
DOI: 10.1007/s00239-001-0060-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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