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Environmental and mutational modulation of collateral fitness effects informs their mechanisms.

Molecular biology and evolution - 1 May 2026

Goff Cameron, Tsou Erh-Yeh, Mehlhoff Jacob D, Ostermeier Marc

Abstract excerpt

Fitness effects of mutations that do not arise from changes in a protein's ability to perform its physiological functions (called collateral fitness effects or CFEs) are an understudied aspect of fitness landscapes. We have previously systematically measured the CFEs of all possible single amino acid substitutions in four proteins and found the frequency of deleterious mutations to vary by two orders of...

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Identifiers

PMID: 42012237
DOI: 10.1093/molbev/msag106
PMCID: PMC13160053

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