Article
Interactions that determine the assembly of a retinoid X receptor/corepressor complex.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002
Ghosh Jagadish C, Yang Xiaofang, Zhang Aihua, Lambert Millard H, Li Hui, Xu H Eric, Chen J Don
Abstract excerpt
The retinoid X receptor (RXR) is a key regulator in multiple signaling pathways because it can form either a homodimer with itself or a heterodimer with members of the class I nuclear receptors. The RXR-containing dimers regulate transcription by recruiting coactivators or corepressors to the target promoters. The binding of coactivators to RXR is mediated through a hydrophobic pocket formed in part by the...
Topics
- Amino Acid Sequence
- Binding Sites
- Cell Line
- Cell Nucleus
- DNA
- DNA-Binding Proteins
- Dimerization
- Glutathione Transferase
- Humans
- Models, Genetic
- Models, Molecular