Article
Multidomain integration in the structure of the HNF-4α nuclear receptor complex.
Nature - 21 Mar 2013
Chandra Vikas, Huang Pengxiang, Potluri Nalini, Wu Dalei, Kim Youngchang, Rastinejad Fraydoon
Abstract excerpt
The hepatocyte nuclear factor 4α (HNF-4α; also known as NR2A1) is a member of the nuclear receptor (NR) family of transcription factors, which have conserved DNA-binding domains and ligand-binding domains. HNF-4α is the most abundant DNA-binding protein in the liver, where some 40% of the actively transcribed genes have a HNF-4α response element. These regulated genes are largely involved in the hepatic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.