Article
The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor.
The Journal of biological chemistry - 28 Jan 2011
Zhou X Edward, Suino-Powell Kelly M, Xu Yong, Chan Cee-Wah, Tanabe Osamu, Kruse Schoen W, Reynolds Ross, Engel James Douglas, Xu H Eric
Abstract excerpt
Testicular receptors 2 and 4 (TR2/4) constitute a subgroup of orphan nuclear receptors that play important roles in spermatogenesis, lipid and lipoprotein regulation, and the development of the central nervous system. Currently, little is known about the structural features and the ligand regulation of these receptors. Here we report the crystal structure of the ligand-free TR4 ligand binding domain, which...
Topics
- Animals
- Binding Sites
- COS Cells
- Chlorocebus aethiops
- Humans
- Mutation
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Receptors, Steroid
- Receptors, Thyroid Hormone
- Structure-Activity Relationship
- Vitamin A
- Vitamins