Article
Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements.
The Journal of biological chemistry - 20 Dec 2019
Jiang Longying, Dai Shuyan, Li Jun, Liang Xujun, Qu Lingzhi, Chen Xiaojuan, Guo Ming, Chen Zhuchu, Chen Lin, Wei Hudie, Chen Yongheng
Abstract excerpt
Proteins of nuclear receptor subfamily 4 group A (NR4A), including NR4A1/NGFI-B, NR4A2/Nurr1, and NR4A3/NOR-1, are nuclear transcription factors that play important roles in metabolism, apoptosis, and proliferation. NR4A proteins recognize DNA response elements as monomers or dimers to regulate the transcription of a variety of genes involved in multiple biological processes. In this study, we determined two...
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