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Article

Tracing the fates of site-specifically introduced DNA adducts in the human genome.

DNA repair - 1 Mar 2014

Yasui Manabu, Kanemaru Yuki, Kamoshita Nagisa, Suzuki Tetsuya, Arakawa Toshiya, Honma Masamitsu

Abstract excerpt

We developed a system for tracing DNA adducts in targeted mutagenesis (TATAM) and investigated the prevalence and types of consequent mutations. Targeted mutagenesis methods site-specifically replace endogenous DNA bases with bases carrying synthetic adducts using targeting vectors. The TATAM system was enabled by introduction of site-specific DNA double strand breaks (DSB), which strongly enhanced targeting...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24559511
DOI: 10.1016/j.dnarep.2014.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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