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Article

A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.

Biochemistry - 25 Mar 2014

Zhu Rong, Lu Xinping, Pradhan Madhumita, Armstrong Stephen P, Storchan Geoffrey B, Chow Carson C, Simons S Stoney

Abstract excerpt

A gene induction competition assay has recently uncovered new inhibitory activities of two transcriptional cofactors, NELF-A and NELF-B, in glucocorticoid-regulated transactivation. NELF-A and -B are also components of the NELF complex, which participates in RNA polymerase II pausing shortly after the initiation of gene transcription. We therefore asked if cofactors (Cdk9 and ELL) best known to affect paused...

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Identifiers

PMID: 24559102
DOI: 10.1021/bi5000178
PMCID: PMC3985961

Genes

ELL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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