Article
Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.
The Journal of biological chemistry - 1 Jan 2016
Pradhan Madhumita A, Blackford John A, Devaiah Ballachanda N, Thompson Petria S, Chow Carson C, Singer Dinah S, Simons S Stoney
Abstract excerpt
Most of the steps in, and many of the factors contributing to, glucocorticoid receptor (GR)-regulated gene induction are currently unknown. A competition assay, based on a validated chemical kinetic model of steroid hormone action, is now used to identify two new factors (BRD4 and negative elongation factor (NELF)-E) and to define their sites and mechanisms of action. BRD4 is a kinase involved in numerous initial...
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