Article
A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor.
Nucleic acids research - 1 Sept 1998
Brocard J, Feil R, Chambon P, Metzger D
Abstract excerpt
We have developed a new ligand-dependent chimeric recombinase (Cre-GRdex) by fusing the site-specific Cre recombinase to the ligand binding domain (LBD) of a mutant human glucocorticoid receptor (GRdex). The synthetic glucocorticoid receptor (GR) ligands dexamethasone, triamcinolone acetonide and...
Topics
- Aldosterone
- Animals
- Corticosterone
- Dexamethasone
- Glucocorticoids
- Humans
- Hydrocortisone
- Integrases
- Ligands
- Mice
- Mifepristone
- Mutation
- Receptors, Glucocorticoid
- Recombinant Fusion Proteins
- Recombination, Genetic
- Transcriptional Activation
- Triamcinolone Acetonide
- Viral Proteins