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Article

Haplotypes of FcγRIIa and FcγRIIIb polymorphic variants influence IgG-mediated responses in neutrophils.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2014

van der Heijden Joris, Nagelkerke Sietse, Zhao Xiwen, Geissler Judy, Rispens Theo, van den Berg Timo K, Kuijpers Taco W

Abstract excerpt

Human blood neutrophils normally express two FcγRs (FcγRIIa and FcγRIIIb) that, upon multivalent binding of IgG in immune complexes or on opsonized targets, mediate responses such as phagocytosis, Ab-dependent cellular cytotoxicity, and respiratory burst. Allelic variants have been described for both FcγRIIa (131H/R) and FcγRIIIb (NA1/NA2/SH), with different binding affinity for IgG subclasses. Because neither of...

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PMID: 24554771
DOI: 10.4049/jimmunol.1203570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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