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Article

Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.

The Journal of clinical investigation - 1 Jun 1995

Salmon J E, Millard S S, Brogle N L, Kimberly R P

Abstract excerpt

Two classes of receptors for IgG, Fc gamma RIIa and Fc gamma RIIIb, both of which exist in two allelic forms, are expressed on human neutrophils. Neutrophils from normal donors, homozygous for the different allelic phenotypes of Fc gamma RIIIb, have significantly different levels of Fc gamma receptor-mediated phagocytosis of IgG-opsonized erythrocytes (EA). However, the observation that Fc gamma RIIIb mediates...

Topics

Adult
Alleles
Cell Degranulation
Humans
In Vitro Techniques
Middle Aged
Neutrophils
Oxidation-Reduction
Phagocytosis
Reactive Oxygen Species
Receptor Aggregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, IgG

Serine Endopeptidases

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 7769129
DOI: 10.1172/JCI117994
PMCID: PMC295975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769129-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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