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Article

Global footprints of purifying selection on Toll-like receptor genes primarily associated with response to bacterial infections in humans.

Genome biology and evolution - 1 Mar 2014

Mukherjee Souvik, Ganguli Debdutta, Majumder Partha P

Abstract excerpt

Toll-like receptors (TLRs) are directly involved in host-pathogen interactions. Polymorphisms in these genes are associated with susceptibility to infectious diseases. To understand the influence of environment and pathogen diversity on the evolution of TLR genes, we have undertaken a large-scale population-genetic study. Our study included two hunter-gatherer tribal populations and one urbanized nontribal...

Topics

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Bacterial Infections
Evolution, Molecular
Genetic Loci
Genetics, Population
Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Innate

Selection, Genetic

Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 24554585
DOI: 10.1093/gbe/evu032
PMCID: PMC3971583

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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