Article
The selective footprints of viral pressures at the human RIG-I-like receptor family.
Human molecular genetics - 15 Nov 2011
Vasseur Estelle, Patin Etienne, Laval Guillaume, Pajon Sandra, Fornarino Simona, Crouau-Roy Brigitte, Quintana-Murci Lluis
Abstract excerpt
The RIG-I-like receptors (RLRs)--RIG-I, IFIH1 (or MDA5) and LGP2--are thought to be key actors in the innate immune system, as they play a major role in sensing RNA viruses in the cytosol of host cells. Despite the increasingly recognized importance of the RLR family in antiviral immunity, no population genetic studies have yet attempted to compare the evolutionary history of its different members in humans....
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