Article
Population genetic tools for dissecting innate immunity in humans.
Nature reviews. Immunology - 1 Apr 2013
Quintana-Murci Lluís, Clark Andrew G
Abstract excerpt
Innate immunity involves direct interactions between the host and microorganisms, both pathogenic and symbiotic, so natural selection is expected to strongly influence genes involved in these processes. Population genetics investigates the impact of past natural selection events on the genome of present-day human populations, and it complements immunological as well as clinical and epidemiological genetic...
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