Article
Different patterns of Toll-like receptor 2 polymorphisms in populations of various ethnic and geographic origins.
Infection and immunity - 1 May 2012
Ioana M, Ferwerda B, Plantinga T S, Stappers M, Oosting M, McCall M, Cimpoeru A, Burada F, Panduru N, Sauerwein R, Doumbo O, van der Meer J W M, van Crevel R, Joosten L A B, Netea M G
Abstract excerpt
Upon the invasion of the host by microorganisms, innate immunity is triggered through pathogen recognition by pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are the best-studied class of PRRs, and they recognize specific pathogen-associated molecular patterns (PAMPs) from various microorganisms. A large number of studies have shown that genetic variation in TLRs may influence susceptibility to...
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