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Article

High variability of TLR4 gene in different ethnic groups in Iran.

Innate immunity - 1 Jun 2012

Ioana Mihai, Ferwerda Bart, Farjadian Shirin, Ioana Luiza, Ghaderi Abbas, Oosting Marije, Joosten Leo A B, van der Meer Jos W M, Romeo Giovanni, Luiselli Donata, Dediu Dan, Netea Mihai G

Abstract excerpt

Infectious diseases exert a constant evolutionary pressure on the innate immunity genes. TLR4, an important member of the TLR family, specifically recognizes conserved structures of various infectious pathogens. Two functional TLR4 polymorphisms, Asp299Gly and Thr399Ile, modulate innate host defense against infections, and their prevalence between various populations has been proposed to be influenced by local...

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Identifiers

PMID: 21994256
DOI: 10.1177/1753425911423043

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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