Article
Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Human molecular genetics - 1 Dec 2013
Quach Hélène, Wilson Daniel, Laval Guillaume, Patin Etienne, Manry Jeremy, Guibert Jessica, Barreiro Luis B, Nerrienet Eric, Verschoor Ernst, Gessain Antoine, Przeworski Molly, Quintana-Murci Lluis
Abstract excerpt
The study of the genetic and selective landscape of immunity genes across primates can provide insight into the existing differences in susceptibility to infection observed between human and non-human primates. Here, we explored how selection has driven the evolution of a key family of innate immunity receptors, the Toll-like receptors (TLRs), in African great ape species. We sequenced the 10 TLRs in various...
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