Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways

Abstract excerpt

Treatment for childhood acute lymphoblastic leukemia (ALL) requires intensive intrathecal and systemic therapy to reduce the risk of central nervous system (CNS) relapse. This treatment is associated with high rates of neurotoxicity as well as being onerous for both patients and healthcare systems [ 1 ]. Improving CNS-directed therapy, requires understanding of the mechanisms of leukemic survival in this...

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