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Article

Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Patients With Primary CNS Lymphoma Treated With Methotrexate-Based Regimens.

Neurology - 24 Oct 2023

Karschnia Philipp, Kurz Sylvia C, Brastianos Priscilla K, Winter Sebastian F, Gordon Amanda, Jones SooAe, Pisapia Michelle, Nayyar Naema, Tonn Joerg-Christian, Batchelor Tracy T, Plotkin Scott R, Dietrich Jorg

Abstract excerpt

OBJECTIVES: The folate antagonist high-dose methotrexate (HD-MTX) is integral to induction chemotherapy for primary CNS lymphoma (PCNSL); however, it can be associated with leukoencephalopathy. Methylenetetrahydrofolate reductase (MTHFR) is involved in intracellular folate depletion. We assessed whether MTHFR polymorphisms affect the risk of leukoencephalopathy. METHODS: We retrospectively searched our database...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37527941
DOI: 10.1212/WNL.0000000000207670
PMCID: PMC10624483

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