Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors.

PloS one - 1 Jan 2021

Elens Iris, Deprez Sabine, Billiet Thibo, Sleurs Charlotte, Labarque Veerle, Uyttebroeck Anne, Van Gool Stefaan, Lemiere Jurgen, D'Hooge Rudi

Abstract excerpt

This retrospective correlation study investigated the putative link between methylene tetrahydrofolate reductase (MTHFR) A1298C mutations and chemotherapy-related brain function changes in adult childhood-leukemia survivors. To this end, we determined the relationship between the particular MTHFR1298 genotype (AA, AC or CC) of 31 adult childhood-leukemia survivors, and (1) their CSF Tau and phosphorylated Tau...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Survivors
Share to Diffusion Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug-Related Side Effects and Adverse Reactions

Share to Drug Therapy

Share to Folic Acid Antagonists

Share to Intelligence Tests

Share to Methotrexate

Source

Open in PubMed Open full text

Identifiers

PMID: 33930029
DOI: 10.1371/journal.pone.0250228
PMCID: PMC8087097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylene tetrahydrofolate reductase A1298C polymorphisms influence the adult sequelae of chemotherapy in childhood-leukemia survivors.PMID 33930029Read ↗

Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy.Semantic proximity Read ↗

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis.Semantic proximity Read ↗

Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors.Semantic proximity Read ↗

Effect of cancer therapy on neural stem cellsSemantic proximity Read ↗

MTHFR single nucleotide polymorphism associated with working memory in pediatric medulloblastoma survivors.Semantic proximity Read ↗

Genetic mediators of neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Folate pathway gene polymorphisms and risk of childhood brain tumors: results from an Australian case-control study.Semantic proximity Read ↗

Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies.Semantic proximity Read ↗

Association of MTHFR Polymorphisms With Leukoencephalopathy Risk in Patients With Primary CNS Lymphoma Treated With Methotrexate-Based Regimens.Semantic proximity Read ↗

Antioxidant enzyme polymorphisms and neuropsychological outcomes in medulloblastoma survivors: a report from the Childhood Cancer Survivor Study.Semantic proximity Read ↗

Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.