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Article

Influence of ADORA2A gene polymorphism on leukoencephalopathy risk in MTX-treated pediatric patients affected by hematological malignancies.

Pediatric blood & cancer - 1 Nov 2016

Tsujimoto Shin-Ichi, Yanagimachi Masakatsu, Tanoshima Reo, Urayama Kevin Y, Tanaka Fumiko, Aida Noriko, Goto Hiroaki, Ito Shuichi

Abstract excerpt

BACKGROUND: Methotrexate (MTX) can lead to neurotoxicity and asymptomatic leukoencephalopathy. However, the mechanism of MTX-related leukoencephalopathy is obscure. MTX and its metabolites inhibit 5-aminoimidazole-4-carboxamide ribonucleotide formiltransferase (ATIC) and promote adenosine release. Recently, it has been reported that adenosine and its receptor are related to certain central nervous system...

Read the complete abstract on PubMed

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Adenosine A2A

Source

Identifiers

PMID: 27399166
DOI: 10.1002/pbc.26090

Genes

ATIC
ABCB1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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