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Article

Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Aug 2018

Mahmoud Lobna Ben, Mdhaffar Moez, Frikha Rim, Ghozzi Hanen, Hakim Ahmed, Sahnoun Zouheir, Elloumi Moez, Zeghal Khaled

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is a key component of acute lymphoblastic leukemia (ALL) therapy, but it is associated with serious toxicities in a considerable number of patients. OBJECTIVES: The aim of the current study was to determine which variables were associated with MTX toxicity in children, adolescents and young adults with ALL. MATERIAL AND METHODS: In this prospective study, 35 patients with newly...

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Identifiers

PMID: 29911750
DOI: 10.17219/acem/69802

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MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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