Article
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2012
Li Yi-Ping, Ramirez Santseharay, Gottwein Judith M, Scheel Troels K H, Mikkelsen Lotte, Purcell Robert H, Bukh Jens
Abstract excerpt
Hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases worldwide, but treatment options are limited. Basic HCV research required for vaccine and drug development has been hampered by inability to culture patient isolates, and to date only the JFH1 (genotype 2a) recombinant replicates spontaneously in hepatoma cells and releases infectious virus. A JFH1 chimera with the 5' end through NS2...
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