Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional distinctiveness of HLA-A2 allelic variants.

Immunologic research - 1 Sept 2012

Chen Kenneth Yuanxiang, Liu Jingxian, Ren Ee Chee

Abstract excerpt

Human leukocyte antigen (HLA) class I molecules are involved in the presentation of antigenic peptides to CD8(+) cytotoxic T lymphocytes (CTLs), which is important for the development of cellular immunity during viral infections and in cancers. HLA-A2 is one of the most frequent HLA class I specificities and thus is extensively studied structurally and functionally. Since its discovery, more than 300 allelic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Black People
Share to Crystallization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A2 Antigen

Share to Lymphocyte Activation

Share to Molecular Conformation

Share to Structure-Activity Relationship

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 22434516
DOI: 10.1007/s12026-012-8295-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional distinctiveness of HLA-A2 allelic variants.PMID 22434516Read ↗

Genetic diversity of HLA-A2: evolutionary and functional significance.Semantic proximity Read ↗

Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphismsSemantic proximity Read ↗

Identification and functional perspective of a novel HLA-A allele: A*0279.Semantic proximity Read ↗

Identification of a novel HLA-A2 subtype, HLA-A*0216.Semantic proximity Read ↗

Structural aspect of novel HLA-A*02 allele, A*0286, identified by sequence-based typing.Semantic proximity Read ↗

Features of HLA class I expression and its clinical relevance in SARS-CoV-2: What do we know so far?Semantic proximity Read ↗

Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyondSemantic proximity Read ↗

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Semantic proximity Read ↗

Naming HLA diversity: A review of HLA nomenclature.Semantic proximity Read ↗

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.Semantic proximity Read ↗

Sequence of a new HLA-A allele (A*0218) encoding a serological variant, HLA-A2K, observed in Japanese.Semantic proximity Read ↗

Structure of the HLA-A*0211 (A2.5) subtype: further evidence for selection-driven diversification of HLA-A2 antigens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.