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Article

KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C

1 Sept 2017

Abstract excerpt

Killer cell immunoglobulin-like receptors (KIRs) are rapidly evolving species-specific natural killer (NK) cell receptors associated with protection against multiple different human viral infections. We report that the activating receptor KIR2DS2 directly recognizes viral peptides derived from conserved regions of flaviviral superfamily 2 RNA helicases in the context of major histocompatibility complex class I....

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PMID: 28916719
DOI: 10.1126/sciimmunol.aal5296

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