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The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

11 Mar 2015

Abstract excerpt

The engagement of natural killer cell immunoglobulin-like receptors (KIRs) with their target ligands, human leukocyte antigen (HLA) molecules, is a critical component of innate immunity. Structurally, KIRs typically have either two (D1-D2) or three (D0-D1-D2) extracellular immunoglobulin domains, with the D1 and D2 domain recognizing the α1 and α2 helices of HLA, respectively, whereas the D0 domain of the KIR3DLs...

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PMID: 25759384
DOI: 10.1074/jbc.m114.612291

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