Article
LDsplit: screening for cis-regulatory motifs stimulating meiotic recombination hotspots by analysis of DNA sequence polymorphisms.
BMC bioinformatics - 17 Feb 2014
Yang Peng, Wu Min, Guo Jing, Kwoh Chee Keong, Przytycka Teresa M, Zheng Jie
Abstract excerpt
BACKGROUND: As a fundamental genomic element, meiotic recombination hotspot plays important roles in life sciences. Thus uncovering its regulatory mechanisms has broad impact on biomedical research. Despite the recent identification of the zinc finger protein PRDM9 and its 13-mer binding motif as major regulators for meiotic recombination hotspots, other regulators remain to be discovered. Existing methods for...
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