Article
A fine-scale map of recombination rates and hotspots across the human genome.
Science (New York, N.Y.) - 14 Oct 2005
Myers Simon, Bottolo Leonardo, Freeman Colin, McVean Gil, Donnelly Peter
Abstract excerpt
Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the...
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