Article
deltaNp63 has a role in maintaining epithelial integrity in airway epithelium.
PloS one - 1 Jan 2014
Arason Ari Jon, Jonsdottir Hulda R, Halldorsson Skarphedinn, Benediktsdottir Berglind Eva, Bergthorsson Jon Thor, Ingthorsson Saevar, Baldursson Olafur, Sinha Satrajit, Gudjonsson Thorarinn, Magnusson Magnus K
Abstract excerpt
The upper airways are lined with a pseudostratified bronchial epithelium that forms a barrier against unwanted substances in breathing air. The transcription factor p63, which is important for stratification of skin epithelium, has been shown to be expressed in basal cells of the lungs and its ΔN isoform is recognized as a key player in squamous cell lung cancer. However, the role of p63 in formation and...
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