Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program

23 Aug 2016

Abstract excerpt

The p53 family of transcription factors includes p63, which is a master regulator of gene expression in epithelial cells. Determining whether p63 is tumor-suppressive or tumorigenic is complicated by isoform-specific and cellular context-dependent protein associations, as well as antagonism from mutant p53. ΔNp63 is an amino-terminal-truncated isoform, that is, the predominant isoform expressed in cancer cells of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27555661
DOI: 10.1126/scisignal.aag3232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional programPMID 27555661Read ↗

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis.Semantic proximity Read ↗

p63-related signaling at a glanceSemantic proximity Read ↗

Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transitionSemantic proximity Read ↗

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced MetastasisSemantic proximity Read ↗

Distinct interactors define the p63 transcriptional signature in epithelial development or cancerSemantic proximity Read ↗

ΔNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neckSemantic proximity Read ↗

Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes.Semantic proximity Read ↗

p63: the phantom of the tumor suppressor.Semantic proximity Read ↗

p53 associates with and targets ΔNp63 into a protein degradation pathwaySemantic proximity Read ↗

p63: Defining roles in morphogenesis, homeostasis, and neoplasia of the epidermisSemantic proximity Read ↗

p63 and p73 in human cancer: defining the network.Semantic proximity Read ↗

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.