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Article

DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes.

The Journal of biological chemistry - 4 Nov 2011

Oh Ju-Eun, Kim Reuben H, Shin Ki-Hyuk, Park No-Hee, Kang Mo K

Abstract excerpt

p63 is a p53 family protein required for morphogenesis and postnatal regeneration of epithelial tissues. Here we demonstrate that ΔNp63α, a p63 isoform lacking the N-terminal transactivation domain, induces epithelial-mesenchymal transition (EMT) in primary human keratinocytes in a TGF-β-dependent manner. Rapidly proliferating normal human epidermal keratinocytes (NHEK) were infected with retroviral vector...

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Identifiers

PMID: 21880709
DOI: 10.1074/jbc.M111.244939
PMCID: PMC3207403

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DeltaNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes.PMID 21880709Read ↗

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