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Article

p63 induces key target genes required for epidermal morphogenesis

21 Feb 2007

Abstract excerpt

Mice lacking p63, a single gene that encodes a group of transcription factors that either contain (TA) or lack (DeltaN) a transactivation domain, fail to develop stratified epithelia as well as epithelial appendages and limbs. DeltaNp63 isoforms are predominantly expressed during late embryonic and postnatal epidermal development, however, the function of these proteins remains elusive. Using an...

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PMID: 17360634
DOI: 10.1073/pnas.0611376104

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