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Article

TAp63 and DeltaNp63 in cancer and epidermal development.

Cell cycle (Georgetown, Tex.) - 1 Feb 2007

Candi Eleonora, Dinsdale David, Rufini Alessandro, Salomoni Paolo, Knight Richard A, Mueller Martina, Krammer Peter H, Melino Gerry

Abstract excerpt

The epidermis is a multilayered stratified epithelium, continuously regenerated by differentiating keratinocytes, that requires the transcription factor p63 for its development and maintenance. The TP63 gene encodes two major protein isoforms, TAp63 and DeltaNp63, which have both transactivating and transcriptional repressing activities and regulate a wide range of target genes. TAp63 shows clear pro-apoptotic...

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PMID: 17264681
DOI: 10.4161/cc.6.3.3797

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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