Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.

Cancer research - 15 May 2011

Yang Xinping, Lu Hai, Yan Bin, Romano Rose-Anne, Bian Yansong, Friedman Jay, Duggal Praveen, Allen Clint, Chuang Ryan, Ehsanian Reza, Si Han, Sinha Satrajit, Van Waes Carter, Chen Zhong

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant nuclear activation of TP53 and NF-κB family members ΔNp63, cRel, and RelA. However, the mechanisms of cross-talk by which the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Interleukin-8

Share to Ki-67 Antigen

Share to NF-kappa B

Share to Phosphoproteins

Share to Transcription Factor RelA

Source

Open in PubMed Open full text

Identifiers

PMID: 21576089
DOI: 10.1158/0008-5472.CAN-10-3445
PMCID: PMC3443863

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21576089-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation.PMID 21576089Read ↗

Intersection of the p63 and NF‐κB pathways in epithelial homeostasis and diseaseSemantic proximity Read ↗

The p53 Homologue ΔNp63α Interacts with the Nuclear Factor-κB Pathway to Modulate Epithelial Cell GrowthSemantic proximity Read ↗

TNF-α Promotes c-REL/ΔNp63α Interaction and TAp73 Dissociation from Key Genes That Mediate Growth Arrest and Apoptosis in Head and Neck CancerSemantic proximity Read ↗

ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironmentSemantic proximity Read ↗

ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis.Semantic proximity Read ↗

A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissuesSemantic proximity Read ↗

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytesSemantic proximity Read ↗

Distinct interactors define the p63 transcriptional signature in epithelial development or cancerSemantic proximity Read ↗

Complex and variable regulation of ΔNp63 and TAp63 by TGFβ has implications for the dynamics of squamous cell epithelial to mesenchymal transitionSemantic proximity Read ↗

Head and Neck Cancers Promote an Inflammatory Transcriptome through Coactivation of Classic and Alternative NF-κB PathwaysSemantic proximity Read ↗

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced MetastasisSemantic proximity Read ↗

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.